Could you help UAB find targeted new treatments for cancer?

Call it “targeted therapy” or “precision medicine,” but we just call it the cutting edge of cancer research! Part of our hope for the future is finding customized treatments that work very specifically on different cancers and different people. In Alabama, we are lucky to have institutions such as the University of Alabama at Birmingham playing a critical role in this kind of research.

Most recently came the news  that UAB’s Comprehensive Cancer Center is enrolling patients for  the National Cancer Institute Molecular Analysis for Therapy Choice, or NCI-MATCH study, the largest, most scientifically rigorous precision medicine trial in cancer to date.

http://www.uab.edu/news/focus-on-patient-care/item/7469

According to the article, the clinical trial is open to patients whose cancer has returned, has gotten worse after standard treatment, or has no standard treatment at all.

This is the way possible new treatments are usually explored and developed, and those of us who have personally experienced cancer are always indebted to those who went before us and participated in these trials that ultimate saved our lives.

The hope is that researchers will now find even more weapons in their arsenal against this disease, and that the new therapies will attack each cancer where it is vulnerable and in ways that don’t inflict so much collateral damage.

“We are at an exciting point in cancer where we can tailor care to the individual patient based on emerging treatment and prevention that takes into account individual variability in genes, environment and lifestyle for each person,”  Carla Falkson, M.D., professor in the UAB Division of Hematology and Oncology and principal investigator for the trial, is quoted as saying.

The hope is eventually to enroll 3,000 adult patients at UAB in the research study. If you think you might be a candidate, talk with your oncologist. Or to find out more details about eligibility, etc.,  contact Liz Busby, director of Oncology Clinical Trials at the UAB Comprehensive Cancer Center, at 205-934-0337 or [email protected].

New cancer treatment shrinking tumors in clinical trials

2:07 PM, Aug 26, 2015

DENVER – Doctors at the University of Colorado’s Anschutz Medical Campus say they discovered a cancer-causing gene and found drugs to fight it.

The treatment, now in clinical trials, appears to be shrinking tumors — fast.

Patient Nichol Miller, who traveled to Colorado from her home in Oregon, credits the treatment with saving her life. Chemotherapy had stopped working and the tumors in her lungs were still growing, when she first decided to visit Colorado for clinical trials in December.

“When I got my diagnosis, I was like… failure is not an option. I’ll beat this somehow, some way,” said Miller.

She is working with Dr. Robert Doebele, who discovered a cancer-causing gene back in 2012 in another patient. Dr. Doebele says he also found the drugs to block its activity — the same drugs Miller is taking.

The “before and after” pictures of Miller’s lungs show the treatment is working — fast.

“She had very extensive tumor involvement in both lungs,” said Dr. Doebele. “Now, it’s very hard to find involvement in either lung.”

Miller is the first patient in the trial with the abnormal gene. Doebele says her case proves what he discovered in the lab works in humans. Miller hopes others can experience the same success.

“It’s amazing,” she said. “It’s given me back my future.”

The goal is to get FDA approval for the new drug, but Doebele says that will take at least two years.